How Semaglutide Works

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Semaglutide is a GLP-1 Hormone primarily found in the pancreas and gut lining. We consider it a superior regulator of sugar. It doesn’t allow a glycemic index spike, therefore preventing an insulin spike as well. No spikes mean less carriers of glucose to fat storage. Because of this, there is less risk of adverse effects from medications as it also does not lower blood sugar or cause hypoglycemia (less than .001% chance of that happening)

Semaglutide also slows gut motility, causing food to be processed through the intestines as a decreased rate, which, in turn, stimulates an area in the brain that decreases appetite hormones because the pressure signals in your intestines sense food is present in the digestive system. This lowers food cravings and increases satiety. Patients notice and report a decrease in carbohydrate and alcohol cravings.

Semaglutide can speed the metabolism, while burning white AND brown fat (it is imperative to have brown fat to protect organs but excess is not good) and also decreasing inflammation. This is great for patients with PCOS, IBS, Crohn’s Disease, and Arthritis. Studies have also seen overall kidney/renal function, blood pressure, and brain function all improved.  Further studies are being done of the decreased risk to mental decline such as dementia and Alzheimers in Semaglutide patients as well.

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Benefits

The American College of Cardiology and the American Heart Association are endorsing semaglutide from a 16-week period showing where a patient utilizes semaglutide and risk factors for heart attack and stroke decreased by 39% or more (over a two year study and it is projected this statistic would be even higher in a five year study.)

The American Association of Endocrinology study found that the longer you are on semaglutide the more rejuvenation of beta cells were found, decreasing the risk of diabetes long term. 

You do not however, have to take semaglutide forever; if at any point a patient stops injections, their GLP-1 levels will return to natural baseline levels.

Side Effects

  1. Nausea
  2. Belching/burping
  3. Feeling of Constipation
  4. Dehydration (patient may note however, an increase in natural thirst)

Contraindications

  1. Pancreatitis
  2. Type-1 Diabetes
  3. Thyroid Cancer (specifically Medullary Thyroid Cancer)
  4. Pregnant/plan to be pregnant/breastfeeding

How the Program Works

Injection 1x/wk into belly fat 

Max dose is 2.4mg/wk (.5-1mL is where noted studies were done on cardiovascular health benefits)

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M-1 .25mg

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M-2 .50mg

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M-3 .75-1mg

*Try to refrain from titrating before necessary

*Can leave medication at room temp for up to 7 days but may lose potency if not kept cold

*Recommended to combine with Lipo-B or NAD+ injections

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